An isoflavone-enriched diet alleviates Parkinson’s disease in mice by inhibiting ferroptosis through gut microbiota-mediated serotonin production
Our findings reveal a novel dietary-microbiota-serotonergic pathway that mitigates ferroptosis and neurodegeneration, highlighting the therapeutic potential of isoflavone-based interventions for PD.
Authors
- Likai Xie
- Yi Yu (ORCID: https://orcid.org/0000-0003-3790-0945)
- Yan Ma
- Le Yang
- Haiying Wang
Institutions
- People 's Hospital of Jilin Province (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1730833
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00