Prognostic Significance of Different Ki-67 Cutoff Values Defined Luminal B HER2-Negative Breast Cancer
Luminal B (HER2-) breast cancer is defined as ER- or PR-positive and HER2-negative meeting with PR ≤ 20%, or ER- or PR-positive and HER2-negative with high Ki-67 index, which has worse prognoses. The locally specified Ki-67 cutoff value has remained elusive in China. 4940 patients with ER- or PR-positive and HER2-negative operable breast cancer were recruited. The novel findings was that luminal B (HER2-) tumors showed poor DFS regardless of Ki-67 cutoff values (14, 20 or 30%), and luminal B (HER2-) subtype(PR ≤ 20% and high Ki-67 index) tumors showed inferior OS, DMFS, and BCSS. With Ki-67 cutoff value of 20%, it was optimized to distinguish prognostic differences.
Authors
- Min Ji
- Xin Ye
- Zhiwei Wang (ORCID: https://orcid.org/0000-0001-5643-9344)
- Qi He (ORCID: https://orcid.org/0000-0001-6000-2655)
- Jie Wang
- Xiaoyun Zhou
- Li Yang
Institutions
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Shanghai Municipal People's Government (CN)
Publication Details
- Journal
- Cancer Investigation
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1080/07357907.2026.2617267
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00