Gamma tACS as a novel treatment for primary progressive aphasia: A pilot case series of four cases
A recent study found that applying gamma-frequency (40 Hz) transcranial alternating current stimulation (γ-tACS) over the precuneus in Alzheimer’s disease (AD) patients temporarily improved the patients’ episodic memory and function of the cholinergic system.1 γ-tACS incites physiological gamma oscillations in cortical neurons with disturbed or decreased high-frequency oscillatory activity.2 First noted by Assogna et al.3, the cellular death of cortical GABAergic interneurons has been observed in a TARDBP-overexpressing mouse model of frontotemporal dementia (FTD) which might result in a decrease in gamma-frequency oscillations due to the loss of inhibitory control by interneurons.
Authors
- Laura Säïsänen (ORCID: https://orcid.org/0000-0002-8877-1170)
- Sara Määttä (ORCID: https://orcid.org/0000-0001-5402-3417)
- Jelena Hyppönen (ORCID: https://orcid.org/0000-0003-3027-9340)
- Esa Mervaala (ORCID: https://orcid.org/0000-0001-5682-5747)
- Eino Solje
- Johanna Krüger
- Noora-Maria Suhonen
- Annakaisa Haapasalo
- Barbara Borroni
- Vertti Etelämäki
- Kasper Katisko
Institutions
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Kuopio University Hospital (FI)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
Publication Details
- Journal
- Brain stimulation
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1016/j.brs.2026.103046
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suomen Lääketieteen Säätiö
- EU Joint Programme – Neurodegenerative Disease Research
- Suomen Kulttuurirahasto
- Jane ja Aatos Erkon Säätiö
- Sigrid Juséliuksen Säätiö