Arginase-1 Expressing Macrophages and Myofibroblasts Interact to Regulate IGF1-Dependent Tubule Repair
Our results demonstrate that alternatively activated macrophages signal cooperatively with myofibroblasts and possibly endothelial cells to coordinate local IGF1 secretion and proliferative tubule repair at sites of epithelial cell loss after kidney injury. These findings support an important role of activated myofibroblasts in effective tubule repair.
Authors
- Bismark Owusu Frimpong (ORCID: https://orcid.org/0000-0002-0689-3968)
- Leyuan Xu (ORCID: https://orcid.org/0000-0002-3071-9206)
- Bhavya Bharathan
- Lloyd G. Cantley
Institutions
- Yale University (US)
Publication Details
- Journal
- Kidney360
- Published
- 2026-02-02
- DOI
- https://doi.org/10.34067/kid.0000001150
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00