BUB1 promotes lung adenocarcinoma progression by regulating STAT3/GPX4-mediated ferroptosis
Collectively, our findings identify BUB1 as a novel prognostic biomarker and therapeutic target for LUAD, revealing a new regulatory mechanism by which BUB1 promotes LUAD progression through the activation of the STAT3/GPX4 axis to suppress ferroptosis.
Authors
- Jiehao Liao
- Tingwei Li (ORCID: https://orcid.org/0000-0003-2057-440X)
- Xiaocong Mo
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-2016-290X)
- Yin Liu (ORCID: https://orcid.org/0000-0001-6014-061X)
- Mengyuan Zhu (ORCID: https://orcid.org/0000-0003-2652-3902)
- Xiaofen Pan
- Shuo Fang
- Yu Wang
- Bo Wang
Institutions
- Sun Yat-sen University (CN)
- Chongqing University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Xijing Hospital (CN)
- First People's Hospital of Chongqing (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.3389/fonc.2025.1745238
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00