Sex- and Exercise-Dependent Modulation of Hypertrophic Remodeling by the MCT1 rs1049434 Polymorphism
The phenotypic impact of MCT1 rs1049434 in sarcomere-positive HCM is context-dependent. In women, impaired monocarboxylate handling is associated with greater hypertrophic remodeling, whereas in men, exercise-related metabolic conditioning appears to attenuate disease severity. These findings support a genotype-sex-environment interaction relevant to precision medicine approaches in HCM.
Authors
- Natalia Fernández Suárez (ORCID: https://orcid.org/0000-0002-3146-8621)
- María Teresa Viadero
- Teresa Amigo
- José Antonio Benítez‐Muñoz (ORCID: https://orcid.org/0000-0001-5375-5931)
- Rocío Cupeiro
- Domingo González-Lamuño
Institutions
- Universidad de Cantabria (ES)
- Marqués de Valdecilla University Hospital (ES)
- Universidad Alfonso X el Sabio (ES)
- Universidad Politécnica de Madrid (ES)
Publication Details
- Journal
- Genes
- Published
- 2026-02-02
- DOI
- https://doi.org/10.3390/genes17020188
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00