Root coverage of type 2/3 gingival recession using recombinant human fibroblast growth factor‐2 in combination with carbonate apatite granules: A case study

Gum recession is a common dental condition where the gums pull away from the teeth, leaving the roots exposed. This can lead to tooth sensitivity, increased risk of decay, and esthetic concerns. Treating advanced forms-classified as Type 2 and Type 3-is especially difficult because not only are the roots exposed, but the gum tissue between the teeth is also lost. In this case report, two patients with these advanced types of gum recession were treated using a novel approach that combines regenerative materials with a minimally invasive surgical technique. A tissue-regenerating protein called rhFGF-2 was applied to both a synthetic bone substitute (CO<sub>3</sub>Ap) placed between the teeth and to soft tissue taken from the roof of the mouth. This tissue was used to cover the exposed roots. Over the course of follow-up, the treated areas healed well: most of the roots became re-covered with healthy gum tissue, and the tissue between the teeth, although not fully restored, showed clear signs of regeneration. While further studies are needed, this technique may provide a promising new option for patients with difficult-to-treat gum recession, especially in cases where traditional treatments have limited success due to loss of supporting structures.

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Publication Details

Journal
Clinical Advances in Periodontics
Published
2026-02-02
DOI
https://doi.org/10.1002/cap.70031
Primary Topic
Periodontal Regeneration and Treatments
Type
article
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article

Root coverage of type 2/3 gingival recession using recombinant human fibroblast growth factor‐2 in combination with carbonate apatite granules: A case study

Akiyoshi Funato, Chihiro Ishikura, Yusuke Katsuda, Akihiko Katayama
Clinical Advances in Periodontics
Periodontal Regeneration and Treatments
article

Root coverage of type 2/3 gingival recession using recombinant human fibroblast growth factor‐2 in combination with carbonate apatite granules: A case study

Akiyoshi Funato, Chihiro Ishikura, Yusuke Katsuda, Akihiko Katayama
article en

Abstract

Gum recession is a common dental condition where the gums pull away from the teeth, leaving the roots exposed. This can lead to tooth sensitivity, increased risk of decay, and esthetic concerns. Treating advanced forms-classified as Type 2 and Type 3-is especially difficult because not only are the roots exposed, but the gum tissue between the teeth is also lost. In this case report, two patients with these advanced types of gum recession were treated using a novel approach that combines regenerative materials with a minimally invasive surgical technique. A tissue-regenerating protein called rhFGF-2 was applied to both a synthetic bone substitute (CO<sub>3</sub>Ap) placed between the teeth and to soft tissue taken from the roof of the mouth. This tissue was used to cover the exposed roots. Over the course of follow-up, the treated areas healed well: most of the roots became re-covered with healthy gum tissue, and the tissue between the teeth, although not fully restored, showed clear signs of regeneration. While further studies are needed, this technique may provide a promising new option for patients with difficult-to-treat gum recession, especially in cases where traditional treatments have limited success due to loss of supporting structures.

Clinical Advances in Periodontics
Nihon University (JP), Tokyo Dental College (JP), Kanazawa Hospital (JP)
Openalex Percentile: Top 71%
Periodontal Regeneration and Treatments
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Root coverage of type 2/3 gingival recession using recombinant human fibroblast growth factor‐2 in combination with carbonate apatite granules: A case study — Akiyoshi Funato, Chihiro Ishikura, et al. · Clinical Advances in Periodontics (2026) | TGRS Research Map | TGRS