Human milk fat substitutes improve obesity-related NAFLD by enriching LPC 18:2 to activate hepatic GPR119–AMPK signaling
HMFS alleviates diet-induced metabolic impairments in mice by enriching LPC 18:2, which activates GPR119-AMPK signaling to promote hepatic lipid catabolism. These findings provide mechanistic evidence supporting structured lipids as potential nutritional interventions for obesity-related liver disease.
Authors
- Liufeng Zheng
- Zeyuan Deng
- Yangzheng He
- Jing Li
- Yong Sun
- Zhigang Wen
- Hongyan Li
Institutions
- Nanchang University (CN)
- Nanchang Normal University (CN)
- State Key Laboratory of Food Science and Technology (CN)
- Wenzhou Institute of Technology Testing & Calibration (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.01.083
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00