Ginsenoside Rb1 Targets the <scp>HRD1</scp> ‐ <scp>STING</scp> Axis to Mitigate Cholesterol‐Induced <scp>VSMC</scp> Senescence
These findings indicate that Rb1 protects VSMCs against cholesterol-induced senescence by preserving HRD1 expression, mitigating ER stress, and maintaining mitochondrial function. Therefore, Rb1 holds therapeutic potential for preventing vascular diseases associated with VSMC senescence by modulating the HRD1 and STING pathways.
Authors
- N. Lin
- Haiming Niu (ORCID: https://orcid.org/0000-0002-8963-440X)
- Yingzhang Cai
- Miaolian Chen (ORCID: https://orcid.org/0000-0002-0306-5999)
- Linli Wang (ORCID: https://orcid.org/0000-0003-3361-8299)
- Conghui Yu
Institutions
- Sun Yat-sen University (CN)
- Xiamen University (CN)
- Zhongshan People's Hospital (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1002/jcla.70172
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00