Characterization of Distinct Monocyte Subtypes and Immune Features Associated with HIV, Tuberculosis, and Coronary Artery Disease in a Ugandan Cohort Using Mass Cytometry
These findings underscore the complexity of the monocyte landscape in CAD progression, particularly in regions where HIV and TB are co-endemic. Our study reveals distinct alterations within 2 non-classical monocyte subpopulations associated with CAD and with HIV/TB, offering mechanistic insights that may support the development of precision biomarkers and immune-targeted therapies across these disease contexts.
Authors
- Manuel G. Feria (ORCID: https://orcid.org/0000-0001-8569-0343)
- Tecla M. Temu (ORCID: https://orcid.org/0000-0002-0056-4143)
- Cindy Nochowicz
- Moises Arturo Huaman (ORCID: https://orcid.org/0000-0002-6839-5809)
- Celestine N. Wanjalla (ORCID: https://orcid.org/0000-0001-9159-5414)
- Joshua D. Simmons (ORCID: https://orcid.org/0009-0005-8517-4863)
- José Cobeña-Reyes
- Sandr Andorf
- Geofrey Erem
- Cissy Kityo
- Christopher Longenecker
- Sheikh Arafat
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Washington (US)
- Massachusetts General Hospital (US)
- VA Tennessee Valley Healthcare System (US)
- Tennessee Department of Health (US)
- Joint Clinical Research Centre (UG)
- Makerere University (UG)
- Vanderbilt University Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Pathogens and Immunity
- Published
- 2026-01-29
- DOI
- https://doi.org/10.20411/pai.v11i1.945
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences