Incidental 18F-Flortaucipir Uptake in Pituitary Macroadenoma

A 73-year-old woman with over 2 years of progressive memory decline underwent amyloid PET/CT (18F-florbetaben) and tau PET/CT (18F-flortaucipir) imaging for suspected Alzheimer disease (AD). This series of examinations confirmed the diagnosis of AD. Unexpectedly, a pituitary macroadenoma with significant 18F-flortaucipir uptake was revealed, which might represent another instance of off-target binding.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2026-01-22
DOI
https://doi.org/10.1097/rlu.0000000000006313
Primary Topic
Pituitary Gland Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Incidental 18F-Flortaucipir Uptake in Pituitary Macroadenoma

Xiaoming Luo, Min Xiong, Yipei Liu, Sheng‑Nan Jiang
Clinical Nuclear Medicine
Pituitary Gland Disorders and Treatments
article

Incidental 18F-Flortaucipir Uptake in Pituitary Macroadenoma

Xiaoming Luo, Min Xiong, Yipei Liu, Sheng‑Nan Jiang
article en

Abstract

A 73-year-old woman with over 2 years of progressive memory decline underwent amyloid PET/CT (18F-florbetaben) and tau PET/CT (18F-flortaucipir) imaging for suspected Alzheimer disease (AD). This series of examinations confirmed the diagnosis of AD. Unexpectedly, a pituitary macroadenoma with significant 18F-flortaucipir uptake was revealed, which might represent another instance of off-target binding.

Clinical Nuclear Medicine
Second Affiliated Hospital of Guangzhou Medical University (CN), Guangzhou Medical University (CN)
Gender equality
Openalex Percentile: Top 71%
Pituitary Gland Disorders and Treatments
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