Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel
This maternal serum test provides a reliable approach for early risk assessment of sPTB. The three-protein panel demonstrated reproducible performance across cohorts and across PPROM-positive and PPROM-negative phenotypes, with the strongest discrimination in the first and second trimesters, when preventive therapies such as progesterone or cerclage are most effective. These findings support its potential as an early, clinically actionable screening tool for improving pregnancy outcomes.
Authors
- Zhi Han
- Negin Ghafourian
- Richard D. Mortensen
- M. S. Angst
- Jian Tao
- H. J. Cohen
- Ruben Luo
- Gary M Shaw
- Nima Aghaeepour
- Ivana Marić
- Lu Tian
- Jianmin Niu
- David K. Stevenson
- Yixuan Chen
- Yun Ding
- Xuefeng B. Ling
- Xiaohua Luo
- Scott R. Ceresnak
- Kuo-Jung Su
- Gary L. Darmstadt
- Juan Wei
- Naoto Ozawa
- Bo Jin
- Ronald J. Wong
- Takumi Ichikawa
- Linlin Wu
- Karl G. Sylvester
- Qiong Luo
- Brice Gaudilliere
- C. James Chou
Institutions
- Sun Yat-sen University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Henan Provincial People's Hospital (CN)
- New York Life Insurance Company (United States) (US)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Stanford Medicine (US)
- Third Affiliated Hospital of Zhengzhou University (CN)
- OncoPlex Diagnostics (United States) (US)
- Eighth Affiliated Hospital of Sun Yat-sen University
- Stanford University (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1186/s12916-026-04639-9
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00