Lipoxin B <sub>4</sub> Mitigates TRPV4-Activated Müller Cell Gliosis During Ocular Hypertension
Müller glia are a significant source of LXB4 in the retina. This neuroprotective Müller glia pathway is amplified during chronic TRPV4 activation to counter-regulate gliosis. These findings support the targeting of the TRPV4-lipoxin pathway as a potential approach to protect against ocular hypertension-induced neurodegeneration in glaucoma.
Authors
- Shruthi Karnam (ORCID: https://orcid.org/0000-0003-1518-380X)
- John G. Flanagan (ORCID: https://orcid.org/0000-0003-1341-1848)
- Karsten Gronert (ORCID: https://orcid.org/0000-0002-5329-7907)
- Matangi Kumar
- Rama Nagireddy
- Shubham Maurya
Institutions
- University of California, Berkeley (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1167/iovs.67.2.2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00