Taurine attenuates <i>Listeria monocytogenes</i> -induced inflammation and pyroptosis in mouse model by regulating MAPK and NLRP3/caspase-1/GSDMD pathways

<i>Listeria monocytogenes</i> infections are lethal to specific groups. With the antibiotic crisis, new treatments are needed. Taurine, a safe dietary compound, was found to inhibit <i>Listeria</i> growth. It targets both <i>L. monocytogenes</i> virulence and host immunopathology, stimulated T-cell proliferation, and inhibited pyroptosis. We establish taurine as the non-antibiotic agent that decouples bacterial cytotoxicity from inflammation-driven tissue damage, offering an immediately translatable strategy for high-risk infections amid the antibiotic resistance crisis.