Mitochondrial Resilience in Glaucoma: Targeting NAD+ Metabolism and Oxidative Stress in Retinal Ganglion Cell Degeneration with Nicotinamide Riboside and Berberine: Preliminary Clinical Evidence
The clinical trends identified in this retrospective cohort have substantiated the translational significance of NR + BBR supplementation as a potential adjunctive approach in glaucoma management. NAD<sup>+</sup> repletion and engagement of the AMPK-SIRT-NRF2 pathway may enhance mitochondrial resilience in RGCs. Collectively, these findings offer initial clinical evidence advocating for additional controlled studies on NR + berberine supplementation, while mechanistic interpretations have been derived from the existing literature and are hypothesis-generating.
Authors
- F. Cappellani (ORCID: https://orcid.org/0009-0007-6807-9455)
- Alfonso Spinello
- Caterina Gagliano (ORCID: https://orcid.org/0000-0001-8424-0068)
- Alessandro Avitabile (ORCID: https://orcid.org/0009-0003-1051-876X)
- Giuseppe Gagliano (ORCID: https://orcid.org/0009-0006-0059-5253)
- Matteo Capobianco (ORCID: https://orcid.org/0009-0009-2969-8610)
- Ludovica Cannizzaro (ORCID: https://orcid.org/0009-0001-7556-6952)
- F Visalli (ORCID: https://orcid.org/0009-0005-6710-2460)
- Marco Zeppieri
Institutions
- University of Udine (IT)
- University of Trieste (IT)
- Università degli Studi di Enna Kore (IT)
- University of Catania (IT)
- Istituto di Studi sul Mediterraneo (CNR - ISMed) (IT)
Publication Details
- Journal
- Diseases
- Published
- 2026-02-02
- DOI
- https://doi.org/10.3390/diseases14020056
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00