The Effect of Extracellular Vesicles Produced by MMSC on the Growth Rate of Cultured Renal Epithelial Cells under Normal Conditions and under Oxygen-Glucose Deprivation

This study characterizes extracellular vesicles (EVs) produced by multipotent mesenchymal stromal cells (MMSCs) in culture medium. The vesicles isolated by centrifugation contained proteins specific to exosomes and had a characteristic size. The effects of vesicles produced by MMSC (MMSC-EVs) on kidney cells under normal and pathological conditions were analyzed. MMSC-EVs increased the proliferation rate of renal epithelial cells after damage caused by oxygen-glucose deprivation. The microRNA expression profile in MMSC-EVs showed that both damage-aggravating and protective microRNAs were highly expressed in them. The overall effect of MMSC-EVs on kidney cells appears to result from the complex interactions of protein signals and the regulatory effects of microRNAs.