Normative brain variability, clinical dimension, and molecular‐transcriptomic correlates of bipolar risk in depressed patients

Our findings aid in better understanding the underlying neurobiological mechanisms of emotional states transition and clinically subtle symptom changes in early-stage BD patients who have never experienced a mania/hypomania episode, providing important target information for early intervention in BD.

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Publication Details

Journal
Psychiatry and Clinical Neurosciences
Published
2026-02-02
DOI
https://doi.org/10.1111/pcn.70028
Primary Topic
Bipolar Disorder and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Normative brain variability, clinical dimension, and molecular‐transcriptomic correlates of bipolar risk in depressed patients

ZhiLu Chen, Qian Liao, Cong Pei, Yuxuan Wang et al.
Psychiatry and Clinical Neurosciences
Bipolar Disorder and Treatment
article

Normative brain variability, clinical dimension, and molecular‐transcriptomic correlates of bipolar risk in depressed patients

ZhiLu Chen, Qian Liao, Cong Pei, Yuxuan Wang, Qianqian Lü, Lingling Hua, Xinyi Wang, Junneng Shao, Wei Zhang, Zhijian Yao, Li Xue, Ting Wang
article en

Abstract

Our findings aid in better understanding the underlying neurobiological mechanisms of emotional states transition and clinically subtle symptom changes in early-stage BD patients who have never experienced a mania/hypomania episode, providing important target information for early intervention in BD.

Psychiatry and Clinical Neurosciences
Nanjing Normal University (CN), Ministry of Education (CL), Nanjing Brain Hospital (CN), Southeast University (CN), Nanjing Medical University (CN), Nanjing University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 71%
Bipolar Disorder and Treatment
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