Leukocyte-rich versus leukocyte-poor platelet-rich plasma and hyaluronic acid for knee osteoarthritis: a systematic review and network meta-analysis

Intra-articular PRP provides clinically significant functional improvement and pain relief for patients with KOA, with an efficacy superior to that of HA. Both L-PRP and LP-PRP are effective treatment options with comparable efficacy based on current evidence. Although qualitative trends suggest a potentially better safety profile for LP-PRP, robust data are lacking. Therefore, there is insufficient evidence to recommend one PRP formulation over the other.