Elucidation of the mechanism of Jinmaitong against Diabetic peripheral neuropathy based on a combined strategy of network pharmacology and molecular biology
JMT promotes the polarization of macrophages from the M1 to M2 phenotype and alleviates neuroinflammation in T2DM rats with DPN, which is associated with inhibition of the JAK2/STAT3 signaling pathway. These findings highlight the neuroprotective potential of JMT through immunomodulatory mechanisms.
Authors
- Danian Qin
- Ziman Yu
- Bingjia Zhao (ORCID: https://orcid.org/0000-0003-2832-5694)
- Dan Yang
- Xiaochun Liang
- Yanfei Che
- Hangqi Liu
- Wei Song
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1186/s13020-025-01300-0
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00