Early postnatal changes in thyroid-stimulating hormone and subsequent neurodevelopment in preterm infants
Preterm infants with persistently low or decreasing TSH trajectories showed reduced odds of neurodevelopmental impairment. In contrast, persistently high or increasing TSH levels may instead reflect alternative patterns of postnatal HPT-axis adaptation. Corresponding group differences in fronto-limbic regions at discharge provide neurobiological support that altered thyroid function may contribute to atypical brain connectivity underlying later neurodevelopmental outcomes.
Authors
- Habyeong Kang (ORCID: https://orcid.org/0000-0001-9978-7525)
- Gang-Yi Lee
- Woochang Hwang (ORCID: https://orcid.org/0000-0003-0876-7305)
- Yong Hun Jang
- Dong Hye Ye (ORCID: https://orcid.org/0000-0002-9186-4095)
- Min‐Gyu Yoo (ORCID: https://orcid.org/0000-0002-8153-6813)
- Hyun Ju Lee
- Seung Yang
Institutions
- Georgia State University (US)
- Hanyang University Seoul Hospital (KR)
- Hanyang University (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fendo.2025.1745327
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea