Complement activation and M2-like macrophage accumulation in anti-MDA5 monoclonal antibody–induced hepatic injury in mice
Complement activation and the accumulation of M2-like macrophages are associated with anti-human MDA5 monoclonal antibody-induced hepatic injury in mice. These findings provide mechanistic insight into antibody-complement-macrophage interactions and suggest that modulation of complement pathways may represent a potential therapeutic approach to limit liver and systemic involvement in this disorder.
Authors
- Hironao Hozumi (ORCID: https://orcid.org/0000-0001-5439-1543)
- Yoshiaki Zaizen
- Hiroshi Mukae (ORCID: https://orcid.org/0000-0002-1429-5706)
- Noriho Sakamoto (ORCID: https://orcid.org/0000-0002-7577-476X)
- T. Koga
- Tomoaki Hoshino (ORCID: https://orcid.org/0000-0002-0459-4913)
- Hironori Kusano (ORCID: https://orcid.org/0000-0002-9911-2007)
- T Suda
- Takumi Kawaguchi (ORCID: https://orcid.org/0000-0002-7064-4325)
- Hiroyuki Suzuki (ORCID: https://orcid.org/0000-0003-2383-5038)
- Suzuna Sugi
- Jun Akiba
Institutions
- Kurume University (JP)
- Hamamatsu University School of Medicine (JP)
- Kurume University Hospital (JP)
- Frederick National Laboratory for Cancer Research (US)
- Center for Cancer Research (US)
- Nagasaki University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1707202
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Cancer Institute