Pembrolizumab-Induced Primary Adrenal Insufficiency: A Rare But Life-Threatening Endocrine irAE

Pembrolizumab, a PD-1 checkpoint inhibitor, is widely used in the treatment of various malignancies. While it improves overall survival, it can lead to immune-related adverse events (irAEs), including rare endocrine disorders such as primary adrenal insufficiency (PAI). We present a case of PAI induced by Pembrolizumab in a 75-year-old man, emphasizing the importance of early recognition and timely management.

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Publication Details

Journal
Advances in Clinical Medical Research and Healthcare Delivery
Published
2026-02-01
DOI
https://doi.org/10.53785/2769-2779.1341
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00
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article

Pembrolizumab-Induced Primary Adrenal Insufficiency: A Rare But Life-Threatening Endocrine irAE

Syeda Sarah Raza, Abdullah A Orakzai, Mehr A Orakzai
Advances in Clinical Medical Research and Healthcare Delivery
Cancer Immunotherapy and Biomarkers
article

Pembrolizumab-Induced Primary Adrenal Insufficiency: A Rare But Life-Threatening Endocrine irAE

Syeda Sarah Raza, Abdullah A Orakzai, Mehr A Orakzai
article en

Abstract

Pembrolizumab, a PD-1 checkpoint inhibitor, is widely used in the treatment of various malignancies. While it improves overall survival, it can lead to immune-related adverse events (irAEs), including rare endocrine disorders such as primary adrenal insufficiency (PAI). We present a case of PAI induced by Pembrolizumab in a 75-year-old man, emphasizing the importance of early recognition and timely management.

Advances in Clinical Medical Research and Healthcare DeliveryVol. 6(1)
Good health and well-being
Openalex Percentile: Top 70%
Cancer Immunotherapy and Biomarkers
DOIOpen Access PDFOpenAlex
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Pembrolizumab-Induced Primary Adrenal Insufficiency: A Rare But Life-Threatening Endocrine irAE — Syeda Sarah Raza, Abdullah A Orakzai, et al. · Advances in Clinical Medical Research and Healthcare Delivery (2026) | TGRS Research Map | TGRS