A case of Human Pegivirus acute febrile infection diagnosed by Next Generation Sequencing (NGS)
This case report describes a patient with prolonged fever following a stay in Kinshasa, Democratic Republic of the Congo (DRC). The patient was initially treated for malaria in Kinshasa but was subsequently hospitalized upon returning to Italy. Comprehensive diagnostic investigations, including serological, microbiological, and imaging studies, were conducted. Ultimately, Next Generation Sequencing (NGS) enabled the identification of Human Pegivirus as the likely causative agent, leading to a definitive diagnosis and clinical improvement. This report highlights the diagnostic challenges posed by tropical febrile illnesses and emphasizes the valuable role of NGS in detecting elusive pathogens.
Authors
- Roberto Giuseppetti (ORCID: https://orcid.org/0000-0001-9958-164X)
- Michele Sonnessa
- Rossella Brandi (ORCID: https://orcid.org/0000-0003-0955-845X)
- Emilio D’Ugo (ORCID: https://orcid.org/0000-0001-5852-7575)
- Paola Bucci (ORCID: https://orcid.org/0000-0003-0615-1013)
- Fabio Magurano (ORCID: https://orcid.org/0000-0002-0394-7043)
- Melissa Baggieri (ORCID: https://orcid.org/0000-0002-0226-7599)
- Luca Corrent
- Silvia Fillo
- AnnaTeresa Palamara
- Florigio Lista
- Silvia Gioacchinii
- Anna Anselmo
Institutions
- Roma Tre University (IT)
- Istituto Superiore di Sanità (IT)
- Ministry of Defence (IT)
- Istituto Nazionale Biostrutture e Biosistemi (IT)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1016/j.ijid.2026.108454
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00