High-throughput drug screening for targeting polyploid cancer cells with an interactive web portal
• Cell morphology analysis enables precise PGCC detection and drug efficacy analysis. • High-throughput screen identified anti-PGCC drugs across six cancer types. • PGCC Explorer offers interactive access and genomic analysis for drug discovery.
Authors
- Hsiao-Chun Chen
- Yu‐Chiao Chiu (ORCID: https://orcid.org/0000-0003-1647-8634)
- Chien-Hung Shih
- Jinxiong Cheng (ORCID: https://orcid.org/0000-0002-0667-8707)
- Li‐Ju Wang (ORCID: https://orcid.org/0000-0003-2745-2819)
- Hsi-Chun Wang
- Tiffany Habib
- Huikang Ye
- Shailrajsinh H. Jhala
- Ying-Ju Lai
- Yuan Zhang
- Yushu Ma
Institutions
- University of Pittsburgh (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Cancer Letters
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1016/j.canlet.2026.218289
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00