Induced pluripotent stem cell-derived platelets kill multidrug-resistant Staphylococcus aureus via Toll-like receptor 2-MyD88 signaling and immunoglobulin G/FcγRIIA engagement

Collectively, our findings highlight the direct antimicrobial potential of iPSC-PLTs and provide mechanistic insights, particularly into the contribution of the Toll-like receptor-MyD88 axis. This study provided a basis for applying iPSC-PLTs as a novel therapeutic modality for combating MRSA infections and a genetically modifiable platform for investigating unknown platelet function within the context of antimicrobial immunity.

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Publication Details

Journal
Research and Practice in Thrombosis and Haemostasis
Published
2026-02-01
DOI
https://doi.org/10.1016/j.rpth.2026.103374
Primary Topic
Platelet Disorders and Treatments
Type
article
Field-Weighted Citation Impact
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article

Induced pluripotent stem cell-derived platelets kill multidrug-resistant Staphylococcus aureus via Toll-like receptor 2-MyD88 signaling and immunoglobulin G/FcγRIIA engagement

Sou Nakamura, Shigetada Kawabata, Ieva Stirblytė, Masao Yamaguchi et al.
Research and Practice in Thrombosis and Haemostasis
Platelet Disorders and Treatments
article

Induced pluripotent stem cell-derived platelets kill multidrug-resistant Staphylococcus aureus via Toll-like receptor 2-MyD88 signaling and immunoglobulin G/FcγRIIA engagement

Sou Nakamura, Shigetada Kawabata, Ieva Stirblytė, Masao Yamaguchi, Naoshi Sugimoto, Koji Eto, Victor Nizet, Kimiko Nonomura, Qirui Lin, Satoshi Uchiyama, Katsue Suzuki-Inoue, Miki Nagao
article en

Abstract

Collectively, our findings highlight the direct antimicrobial potential of iPSC-PLTs and provide mechanistic insights, particularly into the contribution of the Toll-like receptor-MyD88 axis. This study provided a basis for applying iPSC-PLTs as a novel therapeutic modality for combating MRSA infections and a genetically modifiable platform for investigating unknown platelet function within the context of antimicrobial immunity.

Research and Practice in Thrombosis and HaemostasisVol. 10(2)
Osaka University of Economics (JP), Chiba University (JP), Kyoto University (JP), University of California San Diego (US), National Institute of Biomedical Innovation, Health and Nutrition (JP), University of Yamanashi (JP), University of Montana (US), The University of Osaka (JP)
Zero hunger
Openalex Percentile: Top 72%
Platelet Disorders and Treatments
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Induced pluripotent stem cell-derived platelets kill multidrug-resistant Staphylococcus aureus via Toll-like receptor 2-MyD88 signaling and immunoglobulin G/FcγRIIA engagement — Sou Nakamura, Shigetada Kawabata, et al. · Research and Practice in Thrombosis and Haemostasis (2026) | TGRS Research Map | TGRS