A Cell‐Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus
We identified RANK (TNFRSF11a) expression in human thymic FOXP3<sup>+</sup> Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4<sup>+</sup> tTregs, which in turn may modulate their maturation and proliferation within the thymic environment. Created in BioRender. Biorender, I. (2026) https://BioRender.com/gbrjlpa.
Authors
- Rui M. M. Victorino (ORCID: https://orcid.org/0000-0001-7567-1704)
- Zoe‐Isabella Junginger
- Pedro Rosmaninho
- Ramona Adameck
- Ana E. Sousa
- Afonso R. M. Almeida
Institutions
- University of Lisbon (PT)
- Instituto Gulbenkian de Ciência (PT)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/eji.70132
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia