LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver (Adv. Mater. 7/2026)
Fat-Clearing Nanoplatform In the Research Article by Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee, and co-workers (DOI: 10.1002/adma.202506373), a dual-functional lipid droplet inhibitor integrates two biomolecules onto a porous nanostructure, enabling lipid capture and enzymatic breakdown, while the Pickering emulsion effect enhances droplet stability and lipid management. The platform reduces liver fat and restores lipid balance in a fatty liver mouse model.
Authors
- Jinyoung Park (ORCID: https://orcid.org/0000-0003-3835-1837)
- SunMi Park
- Jae‐Joong Kim (ORCID: https://orcid.org/0000-0002-2714-2282)
- Hyunbeom Lee (ORCID: https://orcid.org/0000-0001-6954-7520)
- In Young Kang (ORCID: https://orcid.org/0009-0003-0660-1771)
- Dae Won Jun (ORCID: https://orcid.org/0000-0002-2875-6139)
- Yeojin Kim (ORCID: https://orcid.org/0009-0009-2647-7046)
- Sanjita Paudel (ORCID: https://orcid.org/0000-0001-5217-6575)
- Seunghee Kim (ORCID: https://orcid.org/0009-0009-3745-8385)
- Suyeon Kim (ORCID: https://orcid.org/0000-0003-1598-0788)
- Seung‐Hoi Koo
- Hyun Sung Kim
- Joonseok Lee
Institutions
- Korea University (KR)
- Seoul Medical Center (KR)
- Bio-Medical Science (South Korea) (KR)
- Hanyang University (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Advanced Materials
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/adma.72127
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00