Oncolytic virus OH2 induces PD-L1 upregulation via NF-κB signaling and synergizes with anti-PD-L1 therapy in prostate cancer through a targeted extracellular vesicle delivery system
This study identifies a mechanism of OH2-induced PD-L1 expression in PCa and provides a versatile, targeted delivery platform that enables effective intravenous viro-immunotherapy, overcoming key translational barriers.
Authors
- Qi‐Dong Xia (ORCID: https://orcid.org/0000-0002-2278-1122)
- Ye An (ORCID: https://orcid.org/0000-0003-0580-203X)
- Jian‐Xuan Sun (ORCID: https://orcid.org/0000-0003-2667-1200)
- Chen‐Qian Liu
- Jin‐Zhou Xu (ORCID: https://orcid.org/0000-0002-2696-2238)
- S. Wang
- Si-Han Zhang (ORCID: https://orcid.org/0000-0003-0647-690X)
- Yifan Xiong (ORCID: https://orcid.org/0000-0002-1921-7424)
- Zhi-Yu Xia
- Bin-Lei Liu
- Zi-Yi Zhang
- Ci-Xiang Guo
- Jia Hu
- Wei Guan
Institutions
- Wuhan YZY Biopharma (China) (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University of Technology (CN)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1136/jitc-2025-013818
- Citations
- 1
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 30.93
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation