Corallomycetellains A–J, Cytotoxic Epipolythiodioxopiperazine Alkaloids Isolated from the Fungi Corallomycetella repens HDN23-0007
Ten new epipolythiodioxopiperazine (ETP) alkaloids, named corallomycetellains A-J (<b>1</b>-<b>10</b>), along with one known analogue, haematocin (<b>11</b>), were isolated from the fungi <i>Corallomycetella repens</i> HDN23-0007. Their structures, including absolute configurations, were established by comprehensive spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds <b>1</b>-<b>2</b> represent the first two examples of aranotin-type ETPs possessing an aromatic indole moiety. Compounds <b>2</b>-<b>4</b> all featured a unique <i>C</i>2-methyl disulfide substituent, whereas compound <b>4</b> additionally possessed a <i>C</i>2'-oxomethyl group. In in vitro cytotoxicity assays, compounds <b>7</b>-<b>10</b>, which contained <i>α</i>-<i>α</i>' polysulfide bridges, exhibited strong anticancer activity, with IC<sub>50</sub> values ranging from 1.1 to 9.3 μM.
Authors
- qian che
- T Zhu (ORCID: https://orcid.org/0000-0003-4185-5593)
- D. D. Li
- Wenxue Wang (ORCID: https://orcid.org/0000-0002-3469-1765)
- Luning Zhou (ORCID: https://orcid.org/0000-0001-5283-4769)
- Chenqi Zhang
- Shuo Zhao
- Xiaomin Zhang
- Mei Han
Institutions
- Qingdao University (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Marine Drugs
- Published
- 2026-02-01
- DOI
- https://doi.org/10.3390/md24020062
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities