AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRASG12C mutation colorectal cancer liver metastasis
AKR1B10 facilitated immune evasion of KRAS<sup>G12C</sup> mutation CRLM by recruiting and reprogramming neutrophils to remodel the immunosuppressive TME, providing a potential therapeutic target for KRAS<sup>G12C</sup> mutation CRLM patients.
Authors
- Xinyu Jiang (ORCID: https://orcid.org/0000-0001-6820-231X)
- Wenkang Yuan
- Canliang Lu (ORCID: https://orcid.org/0000-0001-5423-2972)
- Tianqi Wang (ORCID: https://orcid.org/0000-0002-7503-602X)
- Jieliang Zuo
- Anhai Yu
- Daoyue Wang
- Shiwei Zhang
- Jiale Chen
- Xiangyu Ivy Wang
- Zihao Du
- Shuhao Zheng
- Tingting Shen
- Chong Zhang
- Xiaowen Feng
- Chao Zhang
- Songlin Xing
- Xuefu Wang
- Weiwei Li
Institutions
- Tongji University (CN)
- Anhui Medical University (CN)
- Shanghai Tenth People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- West Anhui University (CN)
- Huashan Hospital (CN)
- Lu'an First People's Hospital (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s13046-026-03653-2
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.00