Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk

Both FH and PRS are associated with CMD risk and provide complementary but distinct insights into disease risk. PRS adds predictive value beyond FH and partially mediates its effect. Integration of both measures may enhance risk stratification and guide precision prevention strategies.

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Publication Details

Journal
BMC Medicine
Published
2026-02-03
DOI
https://doi.org/10.1186/s12916-026-04666-6
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk

Knightess Oyibo, Sally N. Adebamowo, Ebuka Onyenobi, Michael Zhong
BMC Medicine
Genetic Associations and Epidemiology
article

Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk

Knightess Oyibo, Sally N. Adebamowo, Ebuka Onyenobi, Michael Zhong
article en

Abstract

Both FH and PRS are associated with CMD risk and provide complementary but distinct insights into disease risk. PRS adds predictive value beyond FH and partially mediates its effect. Integration of both measures may enhance risk stratification and guide precision prevention strategies.

BMC MedicineVol. 24(1)
University of Maryland, Baltimore (US)
Good health and well-being
Openalex Percentile: Top 66%
Genetic Associations and Epidemiology
DOIOpen Access PDFOpenAlex
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Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk — Knightess Oyibo, Sally N. Adebamowo, et al. · BMC Medicine (2026) | TGRS Research Map | TGRS