Chimeric Glycoprotein Nanoparticles Elicit Robust Neutralizing Antibodies Against Epstein–Barr Virus (Adv. Mater. 7/2026)

EBV Vaccine Cong Sun, Zheng Liu, Mu-Sheng Zeng, and colleagues design a chimeric nanoparticle displaying multiple EBV glycoproteins in virion-mimicry pattern. It induces potent neutralizing antibodies against Epstein-Barr virus. This vaccine offers a new strategy to comprise multiple antigens upon nanoparticle to induce a native virus-like humoral response with enhanced immunogenicity. The cover image depicts battles between warriors and monster Tao-Wu from ancient Chinese myth. EBV, like monster Tao-Wu is difficult to fight, and the warrior use shield made from the horns of monsters to show the use of glycoproteins of EBV to efficiently combat with it. More details can be found in the Research Article (DOI: 10.1002/adma.202507012).