Comprehensive profiling of the human tear fluid miRNome using small RNA sequencing
This study defines a high-resolution reference profile of the human tear fluid miRNome, demonstrating its stability, diversity, and functional relevance. These data establish a robust baseline for future studies investigating disease-associated alterations in tear miRNAs. Observed demographic associations remain exploratory and require larger, adequately powered cohorts.
Authors
- Shruti Sharma (ORCID: https://orcid.org/0000-0001-7369-0776)
- Saleh Ahmed (ORCID: https://orcid.org/0009-0000-8271-5234)
- Eliza Williams (ORCID: https://orcid.org/0000-0002-3710-8504)
- Garrett Jones
- Pamela M. Martin (ORCID: https://orcid.org/0000-0001-6278-4953)
- Amy Estes
- Jeremy Altman
- Drew Mayernik
- Tae Jin Lee
- Cintia S.de Paiva
- Ashok Sharma
Institutions
- Baylor College of Medicine (US)
- Augusta University (US)
- Augusta University Health (US)
Publication Details
- Journal
- The Ocular Surface
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1016/j.jtos.2026.01.011
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00