Clinical Warning Signs in Detecting Inborn Errors of Immunity in Children: A Diagnostic Accuracy Systematic Review
Traditional warning signs have good rule-in but poor rule-out value for pediatric IEI. Reliance on these signs alone risks delayed or missed diagnoses, particularly for noninfectious IEI phenotypes. Context-specific criteria and decision-support tools are needed to better capture the breadth of IEI presentations and support timely referral.
Authors
- Svetlana Gadetskaya
- Peter Hsu (ORCID: https://orcid.org/0000-0003-4620-073X)
- Tanzil Islam
- Julia Upton (ORCID: https://orcid.org/0000-0001-5320-4232)
- A. I. Asmanov (ORCID: https://orcid.org/0000-0002-3116-6447)
- L. S. Fedorova (ORCID: https://orcid.org/0000-0003-2663-0273)
- Diego Giampietro Peroni (ORCID: https://orcid.org/0000-0002-0234-1373)
- А.А. Korsunskiy (ORCID: https://orcid.org/0000-0002-9087-1656)
- Ann-Marie Malby Schoos
- Ilya Korsunskiy
- Liat Ashkenazi Hoffnung
- Pasquale Comberiati
- Ekaterina Iakovleva
- Danilo Buonsenso
- Isabel Jemide
- Margarita Andreeva
- Amina Aden
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- University of British Columbia (CA)
- Sechenov University (RU)
- King's College London (GB)
- Sheba Medical Center (IL)
- Hospital for Sick Children (CA)
- Children's Hospital at Westmead (AU)
- Agostino Gemelli University Polyclinic (IT)
- Pirogov Russian National Research Medical University (RU)
- Schneider Children's Medical Center (IL)
- Meyer Children's Hospital (IT)
- Copenhagen Prospective Studies on Asthma in Childhood (DK)
- University of Florence (IT)
Publication Details
- Journal
- The Journal of Allergy and Clinical Immunology In Practice
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jaip.2026.01.026
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00