Incidence and Clinical Significance of Drug‐Induced Antibodies and Hemolytic Anemia Associated With Beta‐Lactam Antibiotics: A Prospective Cohort Study
Beta-lactams exhibit high asymptomatic antibody rates (18.07%) with minimal severe hemolysis risk (0.2%). Protocolized monitoring and HLA screening may optimize safety. This first large-scale prospective cohort quantifies the underrecognized epidemic of subclinical antibody formation, challenging traditional pharmacovigilance frameworks that focus solely on overt hemolysis.
Authors
- Zengzhen Wei (ORCID: https://orcid.org/0000-0003-1554-5946)
- Qin Li (ORCID: https://orcid.org/0000-0003-2223-2139)
- Chunyan Huang (ORCID: https://orcid.org/0000-0002-3638-6166)
- Bo Tan (ORCID: https://orcid.org/0000-0002-9836-7171)
- Li Wang
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/pds.70259
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00