Hepatitis B virus RNA and hepatitis B surface antigen kinetics predict treatment outcomes in children with chronic hepatitis B
Early pgRNA kinetics more accurately predict HBeAg seroconversion, whereas HBsAg dynamics forecast HBsAg loss more effectively, particularly when combined with patient age. This complementary monitoring strategy provides a clinically applicable tool for optimizing personalized management in children with CHB.
Authors
- Jiaying Wu (ORCID: https://orcid.org/0000-0001-5184-4295)
- Yunan Chang
- Tao Hu (ORCID: https://orcid.org/0000-0003-1459-1561)
- Xi Peng (ORCID: https://orcid.org/0000-0001-5020-2792)
- Hongmei Xu
- Jing Zhu
- Peng Hu
- Hong Ren
- Ruiqiu Zhao
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fcimb.2026.1746541
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment