Follicular Helper T Cells and B Cell Maturation in Patients with 22q11.2 Deletion Syndrome and Recurrent Infections
While T cell numbers can often normalize in patients with 22q11.2 Deletion Syndrome, our data indicate significantly altered function as defined by differentially expressed genes and aligned with what is known about T cell senescence. The effect was greatest in the patients with recurrent infection. This would be expected to impact T cell function and may account for ongoing symptoms, reduced B cell maturation, and possibly the risk of immune dysregulation.
Authors
- Montana Knight (ORCID: https://orcid.org/0000-0002-5229-4122)
- Bekah Wang
- Audrey Green
- Kelly Maurer (ORCID: https://orcid.org/0000-0002-2112-8463)
- Victoria Giunta (ORCID: https://orcid.org/0009-0007-0796-2439)
- Daniel E. McGinn
- Kathleen E. Sullivan
- Katherine Beigel
- Nouf Alsaati
- Donna M. McDonald-McGinn
- T. Blaine Crowley
- Sarah E. Henrickson
Institutions
- Children's Hospital of Philadelphia (US)
- Sullivan University (US)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1007/s10875-026-01987-2
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00