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Cancer Invasion Into the BoneHead and neck squamous cell carcinoma (HNSCC) is a type of cancer arising from epithelial cells that line the oral and respiratory tracts.As HNSCC progresses, cancer cells often invade adjacent jawbones, which significantly worsens patient prognosis and quality of life.Although several factors contributing to bone invasion have been identified, the mechanisms regulating how tumors interact with bone-associated tissues have not been fully understood.In a recent review, Tsukasaki M and Takayanagi H summarized the molecular and cellular mechanisms underlying bone invasion in HNSCC.