Congenital <scp>CMV</scp> Infection: Determination of Transplacental Passage of Aciclovir by Ex Vivo Placental Perfusion
The transplacental transfer of aciclovir is low. Despite aciclovir's low molecular weight and hydrophilicity, moderate plasma protein binding and rapid renal elimination may limit placental availability, and the observed transfer was lower than expected for passive diffusion, suggesting involvement of facilitated uptake or efflux mechanisms. These results support the current rationale for high-dose valaciclovir regimens in pregnancy and suggest a potential role for transporter-mediated drug transfer.
Authors
- Marianne Leruez‐Ville
- Julien Stirnemann
- Valentine Faure Bardon
- Helyett Ollivier
- Leo Froelicher Bournaud
- Jean‐Marc Treluyer
- Isidore Gaubert
- Tiffany Guilleminot
- Yves Ville
- Gabrielle Lui
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Sorbonne Université (FR)
- Institut des Neurosciences Paris-Saclay (FR)
- Sorbonne Paris Cité (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/1471-0528.70168
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00