Diagnostic Concordance of Two‐ and Three‐Gene <scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 Molecular Assays in Cameroon: Implications for Efficient Pandemic Response in Low‐ and Middle‐Income Countries

GeneXpert exhibits superiority over ThermoFisher in detecting cases of COVID-19. As expected, agreement between two- and three-genes assays at CT < 20 was excellent, suggesting interoperability of these platforms during outbreaks for high viral loads cases. However, two-genes assays may be decisive to guide decision-making for effective public health response while facing intermediate to low-level viral loads in LMICs.

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Publication Details

Journal
Journal of Clinical Laboratory Analysis
Published
2026-02-01
DOI
https://doi.org/10.1002/jcla.70174
Primary Topic
SARS-CoV-2 detection and testing
Type
article
Field-Weighted Citation Impact
0.00

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article

Diagnostic Concordance of Two‐ and Three‐Gene SARS ‐ CoV ‐2 Molecular Assays in Cameroon: Implications for Efficient Pandemic Response in Low‐ and Middle‐Income Countries

Aude Christelle Ka'e, Evariste Molimbou, Désiré Takou, Aurelie Minelle Kengni Ngueko et al.
Journal of Clinical Laboratory Analysis
SARS-CoV-2 detection and testing
article

Diagnostic Concordance of Two‐ and Three‐Gene SARS ‐ CoV ‐2 Molecular Assays in Cameroon: Implications for Efficient Pandemic Response in Low‐ and Middle‐Income Countries

Aude Christelle Ka'e, Evariste Molimbou, Désiré Takou, Aurelie Minelle Kengni Ngueko, Larissa Gaelle Moko Fotso, Francesca Ceccherini‐Silberstein, Sandrine Claire Djupsa Ndjeyep, Tatiana Anim‐Keng Tekoh, Alfred K. Njamnshi, Collins Ambe Chenwi, Pamela Patricia Tueguem, Christian Ngongang Ouankou, Naomi‐Karell Etame, Rachel Audrey Nayang Mundo, Claudia Alteri, Derrick Tambe Ayuk, Ezechiel Ngoufack Jagni Semengue, Hugues Mba, Carlo‐Federico Perno, Joseph Fokam, Nicaise Ndembi, Grace Angong Beloumou, Alexis Ndjolo, Alex Durand Nka, Maria‐Mercedes Santoro, Luna Colagrossi, Vittorio Colizzi, Halle Gregory Eddy Ekane, Yagai Bouba, Michel Carlos Tommo Tchouaket, Yap Boum, Vincent Kamael Mekel, Jeremiah Efakika Gabisa
article en

Abstract

GeneXpert exhibits superiority over ThermoFisher in detecting cases of COVID-19. As expected, agreement between two- and three-genes assays at CT < 20 was excellent, suggesting interoperability of these platforms during outbreaks for high viral loads cases. However, two-genes assays may be decisive to guide decision-making for effective public health response while facing intermediate to low-level viral loads in LMICs.

Journal of Clinical Laboratory AnalysisVol. 40(4)
University of Rome Tor Vergata (IT), University of N'Djamena (TD), International Vaccine Institute (KR), Université de Yaoundé I (CM), University of Buea (CM), Université de Dschang (CM), University of Milan (IT), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Centre International De Reference Chantal Biya (CM), Saint Camillus International University of Health and Medical Sciences (IT), Good Samaritan Hospital (US), National Aids Control Council (KE), Bambino Gesù Children's Hospital (IT), Institute of Human Virology (NG), National Radiation Protection Agency of Cameroon (CM), Ministry of Public Health (CM)
European and Developing Countries Clinical Trials Partnership
No poverty
Openalex Percentile: Top 68%
SARS-CoV-2 detection and testing
DOIOpen Access PDFOpenAlex
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