Metformin Attenuates Osteoarthritis Progression by Modulating Mitochondrial Dynamics via Activation of the AMPK/Drp1 Pathway
This study demonstrates that metformin delays osteoarthritis progression by activating the AMPK/Drp1 pathway to modulate mitochondrial fission and mitophagy, attenuate oxidative stress, and restore chondrocyte function. These findings provide novel mechanistic insight into the therapeutic potential of metformin in osteoarthritis and highlight mitochondrial dynamics as a promising target for future OA interventions.
Authors
- Ying Jia
- Leilei Qin
- Feilong Li
- Qianshui Hu
- Yaji Yang
- Wei Huang
- Jianye Yang
- Haotian Zhou
- Yu Zhou
Institutions
- Fuling Center Hospital of Chongqing (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Emergency Medical Center (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s540176
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00