Effect of Vulgarin and Epivulgarin on Ischemia–Reperfusion-Induced Pancreatic Injury in Rats: A Biochemical, Molecular, and Histopathological Evaluation

Vulgarin and epivulgarin exhibited significant protective effects against pancreatic I/R injury by reducing oxidative stress and suppressing HMGB1/NF-κB-mediated inflammatory signaling. These findings suggest the therapeutic potential of VLG and EPV in managing acute pancreatitis and related pancreatic injuries.

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Publication Details

Journal
Journal of Experimental Pharmacology
Published
2026-02-01
DOI
https://doi.org/10.2147/jep.s563840
Primary Topic
Pancreatitis Pathology and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Effect of Vulgarin and Epivulgarin on Ischemia–Reperfusion-Induced Pancreatic Injury in Rats: A Biochemical, Molecular, and Histopathological Evaluation

Hanan Ogaly, Maged Abdel-Kader, Gamal Soliman, Rehab Abdel-Rahman et al.
Journal of Experimental Pharmacology
Pancreatitis Pathology and Treatment
article

Effect of Vulgarin and Epivulgarin on Ischemia–Reperfusion-Induced Pancreatic Injury in Rats: A Biochemical, Molecular, and Histopathological Evaluation

Hanan Ogaly, Maged Abdel-Kader, Gamal Soliman, Rehab Abdel-Rahman, Ahmed Foudah, Tariq Aljarba, Saleh Alqasoumi, Hassan Althurwi
article en

Abstract

Vulgarin and epivulgarin exhibited significant protective effects against pancreatic I/R injury by reducing oxidative stress and suppressing HMGB1/NF-κB-mediated inflammatory signaling. These findings suggest the therapeutic potential of VLG and EPV in managing acute pancreatitis and related pancreatic injuries.

Journal of Experimental PharmacologyVol. Volume 18
Prince Sattam Bin Abdulaziz University (SA), Cairo University (EG), King Saud University (SA), National Research Centre (EG)
Prince Sattam bin Abdulaziz University, Deanship of Scientific Research, Prince Sattam bin Abdulaziz University
Good health and well-being
Openalex Percentile: Top 70%
Pancreatitis Pathology and Treatment
DOIOpen Access PDFOpenAlex
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