Macrophage Activation Syndrome–Associated Proteins and Enhanced Interferon‐γ Responsiveness in the Plasma Proteome of Patients With Multisystem Inflammatory Syndrome in Children in a Pretreatment Replication Single‐Center Cohort

We have validated several unique features of the plasma proteome of patients with MIS-C first identified in 2020. Discrepant TRIM21 expression in these two cohorts is due to anti-Ro52 autoantibodies in IVIg-treated patients. These data support the use of plasma cytokine profiling to rapidly diagnose MIS-C.

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Publication Details

Journal
ACR Open Rheumatology
Published
2026-02-01
DOI
https://doi.org/10.1002/acr2.70181
Primary Topic
Kawasaki Disease and Coronary Complications
Type
article
Field-Weighted Citation Impact
0.00
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article

Macrophage Activation Syndrome–Associated Proteins and Enhanced Interferon‐γ Responsiveness in the Plasma Proteome of Patients With Multisystem Inflammatory Syndrome in Children in a Pretreatment Replication Single‐Center Cohort

Emily Yang, Hamid Bassiri, Cara Toland, Audrey R. Odom John et al.
ACR Open Rheumatology
Kawasaki Disease and Coronary Complications
article

Macrophage Activation Syndrome–Associated Proteins and Enhanced Interferon‐γ Responsiveness in the Plasma Proteome of Patients With Multisystem Inflammatory Syndrome in Children in a Pretreatment Replication Single‐Center Cohort

Emily Yang, Hamid Bassiri, Cara Toland, Audrey R. Odom John, Edward M. Behrens, Sarah McCuaig, Paul J. Utz, Katharine C. Konvinse, Laura A. Vella
article en

Abstract

We have validated several unique features of the plasma proteome of patients with MIS-C first identified in 2020. Discrepant TRIM21 expression in these two cohorts is due to anti-Ro52 autoantibodies in IVIg-treated patients. These data support the use of plasma cytokine profiling to rapidly diagnose MIS-C.

ACR Open RheumatologyVol. 8(2)
Johnson & Johnson (United States) (US), Children's Hospital of Philadelphia (US), Stanford Medicine (US), Institute of Infection and Immunity (CA), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 70%
Kawasaki Disease and Coronary Complications
DOIOpen Access PDFOpenAlex
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