Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury

These findings establish PGAM5 as a druggable target in organ injury and identify PD as a natural compound with favorable safety and strong translational potential, providing a foundation for necroptosis-targeted therapeutic development.

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Publication Details

Journal
Journal of Advanced Research
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jare.2026.01.075
Primary Topic
Cell death mechanisms and regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury

Guotao Lu, Weiming Xiao, Keyan Wu, Bo Tu et al.
Journal of Advanced Research
Cell death mechanisms and regulation
article

Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury

Guotao Lu, Weiming Xiao, Keyan Wu, Bo Tu, Xiaowu Dong, Xiaoyu Zhu, Weiwei Chen, Xinyi Liu, Weijuan Gong, Wei Li, Dan Ji, Haibo Li, Zifan Ding, Lin Chen, Qingtain Zhu, Chenchen Yuan, Xingmeng Xu
article en

Abstract

These findings establish PGAM5 as a druggable target in organ injury and identify PD as a natural compound with favorable safety and strong translational potential, providing a foundation for necroptosis-targeted therapeutic development.

Journal of Advanced Research
Toho University (JP), Central South University (CN), Fred Hutch Cancer Center (US), He Eye Hospital (CN), Xiangya Hospital Central South University (CN), Yangzhou University (CN)
Good health and well-being
Openalex Percentile: Top 71%
Cell death mechanisms and regulation
DOIOpen Access PDFOpenAlex
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Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury — Guotao Lu, Weiming Xiao, et al. · Journal of Advanced Research (2026) | TGRS Research Map | TGRS