Treatment for Filler-Induced Alopecia with Concentrated Growth Factors

Hyaluronic acid (HA) is widely used for non-surgical facial rejuvenation but is associated with risks, including rare filler-induced alopecia (FIA) in the temporal and frontal regions. While subcutaneous hyaluronidase (HAase) injection is the standard treatment, we report an alternative approach using concentrated growth factor (CGF) injections. A 29-year-old female presented with a pruritic alopecic patch in the right temporal region that appeared 20 days after receiving HA filler injection. A well-demarcated 6×4 cm alopecic patch persisted despite prior treatment with HAase. The patient subsequently underwent four CGF injections. During the ten-month follow-up, significant hair regrowth was observed. This case suggests that CGF monotherapy is a promising treatment for FIA.

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Publication Details

Journal
Clinical Cosmetic and Investigational Dermatology
Published
2026-02-01
DOI
https://doi.org/10.2147/ccid.s565211
Primary Topic
Facial Rejuvenation and Surgery Techniques
Type
article
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article

Treatment for Filler-Induced Alopecia with Concentrated Growth Factors

FuRen Zhang, JianKe Li, LiHong Zhang, Hong Liu et al.
Clinical Cosmetic and Investigational Dermatology
Facial Rejuvenation and Surgery Techniques
article

Treatment for Filler-Induced Alopecia with Concentrated Growth Factors

FuRen Zhang, JianKe Li, LiHong Zhang, Hong Liu, Xi’An Fu
article en

Abstract

Hyaluronic acid (HA) is widely used for non-surgical facial rejuvenation but is associated with risks, including rare filler-induced alopecia (FIA) in the temporal and frontal regions. While subcutaneous hyaluronidase (HAase) injection is the standard treatment, we report an alternative approach using concentrated growth factor (CGF) injections. A 29-year-old female presented with a pruritic alopecic patch in the right temporal region that appeared 20 days after receiving HA filler injection. A well-demarcated 6×4 cm alopecic patch persisted despite prior treatment with HAase. The patient subsequently underwent four CGF injections. During the ten-month follow-up, significant hair regrowth was observed. This case suggests that CGF monotherapy is a promising treatment for FIA.

Clinical Cosmetic and Investigational DermatologyVol. Volume 19
Shandong Provincial Institute of Dermatology and Venereology (CN), Shandong First Medical University (CN)
Good health and well-being
Openalex Percentile: Top 70%
Facial Rejuvenation and Surgery Techniques
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