Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of <scp> <i>Mbp</i> </scp> Enhancer‐Edited Mouse Lines

Both MESE and MGRE sequences provide biologically meaningful estimates of myelin content in fixed tissue but exhibit contrast-specific sensitivities and biases. MGRE combined with rPCA offers time efficient imaging and robustness in fine white matter structures, supporting its utility for high-resolution preclinical myelin mapping.

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Publication Details

Journal
Magnetic Resonance in Medicine
Published
2026-02-01
DOI
https://doi.org/10.1002/mrm.70275
Primary Topic
Advanced MRI Techniques and Applications
Type
article
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article

Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer‐Edited Mouse Lines

Isabella Gomez, Sean Goldfarb, Alan C. Peterson, Katherine A. Siminovitch et al.
Magnetic Resonance in Medicine
Advanced MRI Techniques and Applications
article

Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of Mbp Enhancer‐Edited Mouse Lines

Isabella Gomez, Sean Goldfarb, Alan C. Peterson, Katherine A. Siminovitch, Marius Tuznik, Yawen Shi, David A. Rudko, Klaudia M. Bednarz, Zhe Wu, Vladimir Grouza, Hooman Bagheri, Thomas Stroh
article en

Abstract

Both MESE and MGRE sequences provide biologically meaningful estimates of myelin content in fixed tissue but exhibit contrast-specific sensitivities and biases. MGRE combined with rPCA offers time efficient imaging and robustness in fine white matter structures, supporting its utility for high-resolution preclinical myelin mapping.

Magnetic Resonance in Medicine
Mount Sinai Hospital (CA), Montreal Neurological Institute and Hospital (CA), University of Toronto (CA), Lunenfeld-Tanenbaum Research Institute (CA), Toronto General Hospital (CA), Siemens (Canada) (CA), Toronto General Hospital Research Institute, McGill University (CA)
Clean water and sanitation
Openalex Percentile: Top 71%
Advanced MRI Techniques and Applications
DOIOpen Access PDFOpenAlex
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Quantitative Comparison of Multi‐Echo Spin Echo and Multi‐Echo Gradient Echo Myelin Water Imaging in a Panel of <scp> <i>Mbp</i> </scp> Enhancer‐Edited Mouse Lines — Isabella Gomez, Sean Goldfarb, et al. · Magnetic Resonance in Medicine (2026) | TGRS Research Map | TGRS