Mixed-Methods to Define Meaningful Change using Exit Interviewand Clinical Trial Data in Patients with Tenosynovial Giant Cell Tumor (TGCT)
The responder definitions were at least a 3-point improvement for PROMIS-PF, a 10% improvement for active ROM, and a 2-point improvement for the Worst Stiffness NRS. Qualitative interviews facilitate integrating the patient perspective in the selection of anchors and defining meaningful change.
Authors
- Nicholas A. Zeringo
- Hans Gelderblom
- Tsion Fikre
- Yipin Han
- William Tap
- Michiel Van De Sande
- Nicholas Bernthal
- Christopher Tait
- Brooke Harrow
- Katelyn N. Cutts
- Amanda Saunders
- Heather L. Gelhorn
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of California, Los Angeles (US)
- Leiden University Medical Center (NL)
- Deciphera Pharmaceuticals (United States) (US)
- Gramercy Research Group (United States) (US)
- Thermo Fisher Scientific (Israel) (IL)
Publication Details
- Journal
- Quality of Life Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s11136-026-04162-7
- Primary Topic
- Musculoskeletal synovial abnormalities and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00