The epistemological trap from the real-world evidence concept

Although data collected outside traditional RCTs are essential to decision-making, the 'real-world' label is a rhetorical construct that obscures study design and introduces an illusion of objective truth. Because all scientific inquiries are limited by the observer's methods, 'real-world' claims are essentially fallacious. To promote transparency, researchers should abandon RWE-related terminology in favor of precise study labeling and explicit disclosures of data source limitations.

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Publication Details

Journal
Journal of Clinical Epidemiology
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jclinepi.2026.112179
Primary Topic
Meta-analysis and systematic reviews
Type
article
Field-Weighted Citation Impact
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article

The epistemological trap from the real-world evidence concept

Rachel Riera, Diego Adão, Rafael Leite Pacheco, Leonardo Y. Kasputis Zanini et al.
Journal of Clinical Epidemiology
Meta-analysis and systematic reviews
article

The epistemological trap from the real-world evidence concept

Rachel Riera, Diego Adão, Rafael Leite Pacheco, Leonardo Y. Kasputis Zanini, Gabriela C.L. Martins
article en

Abstract

Although data collected outside traditional RCTs are essential to decision-making, the 'real-world' label is a rhetorical construct that obscures study design and introduces an illusion of objective truth. Because all scientific inquiries are limited by the observer's methods, 'real-world' claims are essentially fallacious. To promote transparency, researchers should abandon RWE-related terminology in favor of precise study labeling and explicit disclosures of data source limitations.

Journal of Clinical EpidemiologyVol. 192
Hospital São Paulo (BR), Universidade Federal de São Paulo (BR)
Peace, Justice and strong institutions
Openalex Percentile: Top 72%
Meta-analysis and systematic reviews
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