The epistemological trap from the real-world evidence concept
Although data collected outside traditional RCTs are essential to decision-making, the 'real-world' label is a rhetorical construct that obscures study design and introduces an illusion of objective truth. Because all scientific inquiries are limited by the observer's methods, 'real-world' claims are essentially fallacious. To promote transparency, researchers should abandon RWE-related terminology in favor of precise study labeling and explicit disclosures of data source limitations.
Authors
- Rachel Riera
- Diego Adão
- Rafael Leite Pacheco
- Leonardo Y. Kasputis Zanini
- Gabriela C.L. Martins
Institutions
- Hospital São Paulo (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Journal of Clinical Epidemiology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jclinepi.2026.112179
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 0.00