Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy
This study suggests that NGR1 may exert renoprotective effects in DN potentially through MME modulation, which appears to mitigate oxidative stress, inflammation, and fibrosis. The findings indicate MME could serve as a promising therapeutic target, providing preliminary mechanistic insights for developing targeted DN therapies.
Authors
- Xueqin Zhang
- Jinyu Lu
- Mingzhu Liang
- Xu Li
- Huan Hong
- Chen Lu
- Halinuer Shadekejiang
- Xinyu Gan
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1186/s12906-026-05272-y
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00