Noninvasive imaging-based assessment of tumor-associated neutrophils for prognosis and immunotherapy response in gastric cancer: a multicenter study
This study is the first clinically validated noninvasive solution for mapping the TAN infiltration status in gastric cancer. EnmlbaRB effectively stratified the patients based on survival outcomes and immunotherapy responsiveness. This paradigm empowers clinicians to personalize therapeutic sequencing based on evolving TAN biology, thereby addressing the critical need for adaptive treatment strategies for advanced gastric cancer management.
Authors
- Jiang Yu
- Wenbo Zheng
- Sujuan Xi
- Wei Wang
- Zihan Li
- Wencheng Li
- Zepang Sun
- Yuming Jiang
- Md Tauhidul Islam
- James Edward Han
- Chuanli Chen
- Zhenhui Li
- Qingyu Yuan
Institutions
- Sun Yat-sen University (CN)
- University of Washington (US)
- Kunming Medical University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University Cancer Center (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Wake Forest University (US)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
- Stanford University (US)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jare.2026.01.082
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00